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The absence of answers to these questions precludes the establishment of a direct causal relationship between NF1 and YAP1 ubiquitination

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Since Nrf2 upregulates the expression of many antioxidant genes altering the activity of this transcription factor would affect a wide variety of antioxidant systems, which may represent a stronger approach than targeting only one antioxidant enzyme (reviewed in (Hybertson et al

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