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BioNTech and Pfizer announce regulatory approval from German authority Paul-Ehrlich-Institut to commence first clinical trial of COVID-19 vaccine candidates

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The accumulation of lactate in the TME can be reduced through increasing its uptake and utilization by tumor cells, thus reducing its influence on tumor cells and immune cells, or through finding effective targets to cause tumors to undergo aerobic metabolism instead of the Warburg effect, thereby inhibiting tumor invasion