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Considering the fact that Trp is the least abundant amino acid in the cell 48 , we concluded that Trp metabolism involves a unique mechanism that negatively regulates V-ATPase-dependent autophagy via suppressing Gcn4 induction while Gcn2 remains active (Fig

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They are therefore less toxic (LD 50 = 1000-2000 mg/kg) than the cyanogenic compounds above, though they may cause toxicity by other means, e.g

as a single agent for the maintenance treatment of patients with locally advanced or metastatic, non-squamous NSCLC whose disease has not progressed after four cycles of platinum-based first-line chemotherapy