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All these non-HFE gene hemochromatoses are rare or exceptional, however they are not limited to caucasian populations

There is also evidence indicating that B cells significantly assist in the pathogenesis of SS in individuals displaying ectopic germinal center-like structures within their exocrine glands (106) ( Figure 2 )

Among various proposed pathogenic mechanisms, the dysfunction of monoamine neurotransmitters, particularly 5-HT, has attracted significant attention

These findings confirm other studies that reported significantly reduced vitamin E levels in advanced stages of CKD patients (Montazerifar et al., 2010)