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For those living with obesity, the risk of hypogonadism is significantly higher

However, in recent years, dedifferentiation, senescence and other forms of cell death, such as autophagy, pyroptosis and ferroptosis, have been found to be involved in the loss of cells

In addition, albumin has an average plasma half-life of three weeks in humans 1,5 , a feature that is increasingly exploited to improve the pharmacokinetic (PK) properties of short-lived biologics, including peptide hormones, cytokines, coagulation factors, and antibody fragments 6,7,8,9,10,11,12,13,14,15

We undertook a mapping exercise of national surveys that collected haemoglobin measurements to assess the frequency with which the following direct causes of anaemia were measured: (1) chronic diseases, (2) infection, (3) inflammation, (4) micronutrient deficiencies