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4 Cholesterol effects on the tumor immune microenvironment The tumor microenvironment consists of the non-cancerous host cells surrounding the tumor, such as fibroblasts, endothelial cells, neurons, adipocytes, and both adaptive and innate immune cells

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WangLZhangZLiMWangFJiaYZhangFet alP53-dependent induction of ferroptosis is required for artemether to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation

Conversely, a cohort study using standard dietetic advice to produce intentional weight loss in older adults with T2D demonstrated that every 1 kg of weight loss was an associated 34 months survival prolongation [64], and a meta-analysis of RCTs assessing the impact of intentional weight loss on mortality found a 15%, although the mean age of participants was 52 years [65]