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Furthermore, trypsin-treatment or surface biotinylation experiments, which separate extracellularly bound proteins from proteins within the cell, revealed that apoE administered to cells predominantly localized to the plasma membrane (Supplementary Fig

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The extracellular localization of this enzyme proposes its role as a link between environmental stress perception and adaptive response

Importantly, nasal sprays enable rapid absorption through the nasal mucosa, allowing the peptide to bypass first-pass metabolism and enter systemic circulation with greater efficiency