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Axo-dendritic glutamatergic synapses are easily recognizable via electron microscopy due to the thickened appearance of the postsynaptic membrane

Approximately 95% of IGF-1 and IGF-II are bound to IGFBP-3, which makes this protein the major carrier of the insulin-like growth factors in circulation

The diagnosis and indications for treatment are clear for individuals with low plasma levels of vitamin B12 in the setting of megaloblastic anaemia and neuropathy, but the relevance of treatment of vitamin B12 deficiency in the absence of such clinical signs is uncertain

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