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Long exposure to high glucose concentration impairs the responsive expression of g-glutamylcysteine synthetase by interleukin-1b and tumor necrosis factor-a in mouse endothelial cells

Gene expression studies show it activates DNA repair genes and tumor suppressors like p53 while dialing down genes linked to metastasis

PMID: 191 PedersenSSPrauseMWilliamsKBarresRBillestrupN

However, although the challenge inoculum was the same as in the first study, areas of diffuse alveolar damage were detected in six out of eight vaccinated macaques compared with one out of eight control animals euthanized at 7 days, as well as at 35 days