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2420-C THE CONCOMITANT ZONAL QUANTIFICATION OF QSTEATOSIS AND QFIBROSIS USING HISTOINDEX AI DIGITAL PATHOLOGY IMPROVES DETECTION OF LIVER INJURY REGRESSION POST-BARIATRIC SURGERY Vlad Ratziu 1 , Raluca Pais 2 , Judith Aron-Wisnewsky 3 , Frederic Charlotte 4 , Dean Tai 5 , Elaine Lay Khim Chng 5 , Desiree Abdurrachim 6 , Chih-Liang Chin 7 , Saswata Talukdar 7 and Asad Abu Bakar Ali 6 , (1)Sorbonne Universit, Assistance Publique-Hpitaux De Paris, Hpital Piti Salptrire, Institute of Cardiometabolism and Nutrition (ICAN), (2)Aphp, (3)Piti-Salptrire Hospital, (4)Sorbonne Universit, Ican Institute, Hpital Piti-Salptrire, (5)Histoindex Pte Ltd, Singapore, (6)Cardiometabolic Diseases, MSD, Singapore, (7)Cardiometabolic Diseases, Merck & Co., Inc., South San Francisco, CA Background: Conventional microscopy histological reads are semi-quantitative and subjective

Therefore, we examined the hydrogen sulfide (H 2 S) release profile of compound 3b-1 which exhibits the strongest H 2 S-releasing capacityunder various pH conditions and its time-dependent release kinetics