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Description

To improve the solubility of LsBAHD, we simultaneously replace all the 28 isoleucine codons in the codon-optimized LsBAHD gene with the SRC AUA

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Published preclinical studies have evaluated AOD 9604 at microgram-level doses in animal models, with administration routes varying by experimental design

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Most bioactive compounds are produced as secondary metabolites, which can be classified as phenolics, flavonoids, chalcones, terpenoids, carotenoids, anthocyanins, quinones, and others

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In addition, adipose tissue may express molecular dysfunctions characteristic of increased ROS that induces endoplasmic reticulum stress, deterioration of the mitochondrial function, as well as the onset of senescence and an apoptotic profile [47, 48]

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