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Moreover, we showed that mAb M51 binds the MetE immunoprecipitated from Mtb culture supernatant by mAb M29 ( Figure 1C ), confirming (i) the good quality and the right conformation of the native recombinant protein that we produced and (ii) that these two high-specific mAbs recognize different, non-overlapping epitopes in the more Mtb-specific sequence of MetE

This reprogramming is driven by alterations in glycolytic enzymes regulated by the UPS

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