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Histological analysis reveals that aged kidneys accumulate senescent cells primarily in tubular regions, identified by loss of Lamin B1 (LMNB1), elevated senescence-associated -galactosidase activity, and expression of inflammatory IL-6

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The design of the sleeping fusion peptide plasmid is a strategic approach to creating a novel biological tool that combines the capabilities of cell-penetrating peptides, a fluorescent marker, and a DSIP for targeted research applications, particularly in the study of sleep mechanisms and potentially therapeutic interventions