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10.1016/j.freeradbiomed.2020.02.027 34 WangB.ZuoX.PengL.WangX.ZengH.ZhongJ.et al (2021)

Mackenzie PI, Bock KW, Burchell B, Guillemette C, Ikushiro S, Iyanagi T, et al

Given that DAB2IP has been demonstrated to effectively inhibit key pro-inflammatory signaling pathways such as NF-B and TNF, we speculate that DAB2IP may, through its anti-inflammatory function, negatively regulate the formation and development of tertiary lymphoid organs within plaques, thereby mitigating abnormal local immune responses

In particular, curcumin increases the expression of GCL and other detoxifying enzymes via the activation of the nuclear factor E2-related factor 2 (Nrf2)-dependent pathway