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FIGURE 1 Ferroptosis appears to require the presence of specific highly oxidisable phosphatidylethanolamine phospholipids containing the polyunsaturated fatty acids (PUFAs) arachidonic acid and adrenic acid

Phagophores nucleate and expand by integrating membranes from multiple sources such that they become sealed double-membrane autophagosomes that engulf various substances 23

Through a combination of metabolomics and transcriptomics, it was found that malignant breast cancer cell lines (MCF-7 and BCC) exhibit lower activity of the methionine cycle compared to non-malignant cell lines (MCF-10A)

When glutathione concentration is reduced, -glutatmylcysteine formation increases and this dipeptide is converted to pyroglutamic acid in the plasma