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Mechanistically, intra-articular AOD-9604 may stimulate synovial fibroblast proliferation or reduce inflammatory cytokine production in the synovial microenvironment, though direct effects on cartilage are unclear

A key limitation in the field is that only blood and faecal samples are available, and, as discussed above, the current biomarkers for intestinal permeability are not reliable enough to answer this question

Gene activation of CEBPA using saRNA: preclinical studies of the first in human saRNA drug candidate for liver cancer

(1992) Insulin resistance in type 2 (non-insulin-dependent) diabetic patients and their relatives is not associated with a defect in the expression of the insulin-responsive glucose transporter (GLUT-4) gene in human skeletal muscle