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253 The first trial enrolled 234 participants (mean age 48 years) who were unwilling or unable to use positive airway pressure (PAP) therapy, and the second group consisted of 235 participants (mean age 52 years) who had been on consistent PAP therapy for at least three months prior to screening and were expected to continue therapy during the trial

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Following cerebral ischemia, the release of inflammatory cytokines and neurotoxic mediators can be induced through multiple signaling pathways, such as NF-B and STAT3, leading to neuronal damage and death (113)