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Animal models have also demonstrated that PNE alters the development of the mesocorticolimbic system which is important for goal-directed behavior and its ability to modulate neural processes that contribute to drug abuse [166]

CVD are one of the most complex group of diseases, as they have a multifaceted pathomechanism and are subject to a variety of risk factors and genetic predispositions [15], which makes it hard to study chemical toxicity to the cardiovascular system mechanistically