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Aerobic exercise training-induced irisin secretion is associated with the reduction of arterial stiffness via nitric oxide production in adults with obesity

MOTs-C MOTs-C is a naturally occurring mitochondrial peptide that has drawn significant research interest for its role in cellular energy regulation, insulin sensitivity, and metabolic health

This metabolic adaptation can be relevant in triple-negative breast cancers (those lacking ERs, PRs and HER2, which constitute approximately a quarter of breast tumours) that express xCT, which exhibit increased levels of ROS induced by decreased glutamate levels upon glutamine scarcity