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To address these challenges, it is essential to develop ligand scaffolds incorporating bioorthogonal conjugation sites, such as azides or alkynes appropriate for copper-free click chemistry, that are positioned away from the coordination sphere

If you are oestrogen or progesterone deficient, you can correct this with 'natural progesterone' HRT, in the form of a transdermal skin cream

From a dermatological point of view, these molecules became invaluable to prevent and treat chronic skin conditions such as melasma a dark skin discoloration and autoimmune dermatological disorders such as alopecia areata progressive hair loss