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Acknowledgements We sincerely thank the researchers who per formed the relevant GWAS and made the summary statistics publicly available

The injection volumes differ significantly based on concentration, and errors here can mean doubling or halving your intended dose

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This facilitates transmembrane flow of Na + , K + , and Ca 2+ , inducing cell membrane depolarization and activating downstream signaling cascades (Figure 2) (McKay et al., 2007)