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149 SSRIs and tricyclic antidepressants increase BDNF expression in cultured primary astrocytes, and BDNF overexpression in mouse hippocampal astrocytes is sufficient to promote neurogenesis and causes anxiolytic behavior

After the introduction of the New Generation Sequencing (NGS) technology [30], which relies on platforms for high-throughput, massively parallel sequencing that can analyse many genes at once, it was possible to identify the forms of PFIC, from PFIC1 to PFIC13 [4, 8, 11, 33,34,35,36,37]

These latter genera harbor sophisticated genetic arsenals encoding pivotal tryptophan metabolism enzymes (including tryptophan synthase K16187, indoleamine-2,3-dioxygenase IDO K00463, and tryptophan-2,3-dioxygenase TDO K00453) and their corresponding enzymatic machinery (EC:1.13.11.52 and EC:1.13.11.11), which systematically amplify tryptophan metabolite biosynthesis, thereby exponentially accelerating renal fibrotic progression trajectories