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However, irofulven remained inactive in a clinical phase II trial against advanced non-small cell lung cancer [65]

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157 Anheim M, Chamouard P, Rudolf G, Ellero B, Vercueil L, Goichot B, et al

Various effective inhibitors of InhA have been screened, identified, and optimized through a structure-based approach, such as pyrazole derivatives, indole-5-amides [75], alkyl diphenyl ethers, triazole-based diphenyl ethers [76, 77], triclosan derivatives [78], diazaborines [79], acrylamides [80], 4-hydroxy-2-pyridones [65], prothionamide [73], methyl-thiazole series [52], and pyrrolidine carboxamides [81]