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Adaptor proteins involved in these signaling pathways include, growth factor bound protein2 (Grb-2), Grb-2 associated binding protein 1 (Gab1), PI3K, signal transducer and activator of transcription 3 (STAT3), SH2-containing inositol 5-phosphatase 1 (SHIP1), phospholipase C (PLC), SH2 domain-containing tyrosine phosphatase 2 (SHP2) (Liu et al., 2018), and Src homology and collagen homology (Shc) (Saucier et al., 2004)

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Looking at the distribution of toxic metals in these brains using elemental bioimaging techniques has provided background data for a hypothesis that toxic metals play a role in triggering common human neurological disorders

They introduce carbon-carbon double bonds into fatty acids, enhancing sensitivity to ferroptosis through the synthesis of specific PUFAs [107]