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For instance, a study on medium-chain acyl-CoA dehydrogenase deficiency (MCADD) disorder revealed disruptions in phenylalanine, tyrosine, and tryptophan biosynthesis pathways, with potential biomarkers such as PGP (a21:0/PG/F1alpha) and glutathione, demonstrating the importance of metabolomics in promoting our understanding of IEMs [21]

Cryan JF, ORiordan KJ, Cowan CSM, Sandhu KV, Bastiaanssen TFS, Boehme M, Codagnone MG, Cussotto S, Fulling C, Golubeva AV, Guzzetta KE, Jaggar M, Long-Smith CM, Lyte JM, Martin JA, Molinero-Perez A, Moloney G, Morelli E, Morillas E, OConnor R, Cruz-Pereira JS, Peterson VL, Rea K, Ritz NL, Sherwin E, Spichak S, Teichman EM, van de Wouw M, Ventura-Silva AP, Wallace-Fitzsimons SE, Hyland N, Clarke G, Dinan TG (2019) The microbiota-gut-brain axis

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The cohorts analysed were heterogenous, comprising elective (cardiac) surgical patients, traumatic brain injury, sepsis and acute pancreatitis