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Variations in complement pathway genes, especially CFH, C3, C2 , and ARMS2/HTRA1 , increase susceptibility to chronic inflammation and drusen formation (4, 5)

Biomed Pharmacother 159:114265

V.ChernyakB

Tseng E, Walsky RL, Luzietti RA Jr, Harris JJ, Kosa RE, Goosen TC, Zientek MA, Obach RS (2014) Relative contributions of cytochrome CYP3A4 versus CYP3A5 for CYP3A-cleared drugs assessed in vitro using a CYP3A4-selective inactivator (CYP3cide)