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The elimination diet can lead to malnutrition if not carefully monitored, while the specific carbohydrate diet may be challenging to follow and restricts certain foods that are important for overall health

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Yu-Kuan Huang et al

This interaction prevents their binding to Parkin, an E3 ubiquitin ligase, thereby maintaining the protein stability of both PHGDH and FXR1 ( Accumulation of FXR1 further enhances the stability of PSAT1 mRNA and promotes its translation, ultimately upregulating the expression of PHGDH and PSAT1 and activating the de novo serine synthesis pathway