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Their crucial contribution was demonstrating the superior sensitizing effect of copper-based materials: CuO NPs (8020 nm) combined with 1 mM ascorbate reduced IC 5 0 values to 0.010.37 g/mL, achieving sensitization factors of 121620-fold, effective even against drug-resistant cell lines

Safety profiles are favorable (mild somnolence, rare discontinuation), and cost is low, both of which are attractive for adjunctive use while larger, phenotype-stratified RCTs mature