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They are highly diverse and contribute significantly to global oxygen production

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Vascular cell adhesion molecule-1 (VCAM-1) and ICAM-1 levels were found to be elevated in the blood of patients with mild COVID-19 and dramatically elevated in severe cases, decreasing during the convalescence phase ( F3 gene expression in both immune and non-immune cells, potentially contributing to the thromboembolic events observed in COVID-19 patients, particularly in severe cases ( The distinct cytokine profile, characterized by elevated levels of pro-inflammatory cytokines in HUVECs supernatants stimulated by serum from severe COVID-19 patients, suggests a hyperactive inflammatory response that could exacerbate endothelial injury and dysfunction