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It is known that JNK activation is mediated by oxidative stress and plays pathogenic roles in a diverse array of cellular programmes, including cell differentiation, movement, proliferation and death 34

Normally, large AIE nanodots have intense accumulation in organs, such as the liver and kidneys, after intravenous injection, which limits their usage for imaging specific tissues

It does not directly influence pigmentation, oxidative damage, or detox pathways in the body

In the first step, glutamate reacts with cysteine to form -glutamylcysteine under the catalysis of the rate-limiting enzyme, -glutamylcysteine ligase (GCL)