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For example, programmed death ligand-1 (PD-L1) blockade therapy and CD8+ T cells increase ROS levels by releasing interferon gamma (IFN) which promotes the binding of transcription factor STAT1 to the SLC7A11 transcriptional start site, downregulating expression

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PPARa inhibits lipid Peroxidation-Associated neuronal ferroptosis following TSCI After confirming the distribution of PPARa and its restorative effects in TSCI, we investigated whether it modulates ferroptosis