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Iron exchange in the mitochondria is mediated by DMT-1 and classical mitoferrins (Mfrn) 1 and 2 [38], which are incorporated into the electron transport chain and produce ATP under the stimulation of glucose

Histone Kla is significantly increased on the promoters of M2-like genes in the later stage of stimulated M1 macrophage polarization, suggesting that histone Kla probably acts as a lactate clock to promote the switch from an inflammatory phenotype to a steady-state phenotype in macrophages

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Moreover, ferroptosis, which occurs in tumor cells, can spread to neighboring cells via the paracrine release of lipid peroxides (Nishizawa 2021)