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Description

While this construct mimicked the first TCR signal upon CAR binding to its target antigen, they lacked the second signal necessary for efficient T-cell activation

Nyberg and colleagues

The literature search, article review, data extraction and results were completed by the PCRRT co-chairs, who submitted their results to the workgroup for discussion

but note that several studies have suggested that D2-MSNs may also contribute to reward-based motivation 6365 and that MSN subtype-specific actions may depend on different patterns of activation 66 ]