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Curr Top Med Chem 21:26342646 Verza FA, Das U, Fachin AL, et al (2020) Roles of histone deacetylases and inhibitors in anticancer therapy

Oxidative stress arises from a disruption in cellular redox homeostasis, where the production of reactive oxygen species (ROS) exceeds the clearance rate by endogenous antioxidant enzymes and molecular chaperones