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Lead exposure is associated with risk of impaired coagulation in preschool children from an e-waste recycling area

[1] That acyl modification is not incidental chemistry: it is installed by a dedicated enzyme (ghrelin O-acyltransferase) and is required for the peptide to bind and activate GHSR1a

doi: 10.1093/jn/136.1.21 8

Given that some mutant enzymes retain low-level FAD-binding capacity, a gene + high-dose riboflavin synergy strategy has been proposed: in AIFM1 encephalopathies, low-level AAV transduction re-establishes baseline protein expression, while daily riboflavin doses above 400 mg act as a molecular chaperone to stabilize FAD binding a regimen shown to improve ICARS scores and neuroimaging outcomes (54, 75)