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Other Symptoms whether dystonia is the only issue or occurs alongside other movement disorders or neurological symptoms Axis II: Causes and Biological Mechanisms Genetic Factors recognizing the genetic forms, whether inherited or not Acquired Causes like certain medications, toxins, or injuries Brain Imaging Clues identifying areas of the brain that might be damaged Biological Processes such as developmental factors, cellular or metabolic pathways, or immune reactions Whats New and Improved in the Updated Publication

doi: 10.3389/fphar.2020.00042 121 DillmannWH

Animal numbers were chosen with consideration of ethical requirements and the 3Rs principle (replacement, reduction, refinement) to balance statistical sensitivity with minimizing animal use 18

The cause, according to Aretaeus, was sometimes either another chronic disease or even consuming "a copious draught of cold water." [70] [71] The paediatrician Samuel Gee gave the first modern-day description of the condition in children in a lecture at the Hospital for Sick Children, Great Ormond Street, London, in 1887