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NRF2 activity is also regulated by the availability of many binding partners, including a group of bZIP bi-directional transcription regulators named sMaf proteins (MafF, G and K) [200, 201] which, when bound to NRF2, under OS, favor its maintenance inside the nucleus thereby enhancing its activity [202]

Low folate levels are found in up to 38% of patients with depression , and supplementation has been shown to enhance the effectiveness of antidepressants, with one study reporting a 93.3% improvement rate