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Our data indicating that PrP plays a role in mediating copper toxicity in WD warrant future studies to evaluate the therapeutic potential of PrP suppression in this and other disorders of copper metabolism

The leaky gut hypothesis is often linked to the formation of opioid peptides and their subsequent passage through the blood-brain barrier, with the idea that this process may be exacerbated by heightened intestinal permeability

Caspase-independent cell death in AML: caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis