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Proctectomy is recommended only as a last resort 36 as, although highly effective, it is a mutilating procedure with considerable risks, including pelvic nerve damage, presacral abscesses, and delayed perineal wound healing

suggested that inflammatory injury in the intestine might trigger the observed increase in plasma GPX activity, which is associated with increased GPX3 mRNA levels in the kidney [165]

chronic psychological stress lowers antioxidants, including GPx, but practices like mindfulness help

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