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Description

Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway

In contrast, pharmacologically decreasing the biosynthesis of glutathione leads to increases in cytosolic glutamate and enhanced mEPSC frequency

Tokunaga, Keisuke

Patients with breast cancer need personalised treatment strategies on the basis of their distinct molecular characteristics due to the unique epidemiological patterns and high heterogeneity of breast cancer, which limits therapeutic efficacy and poses significant challenges to current treatments