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We found that H19 mainly regulates oxidative stress and cell-cycle genes and the primary route of cisplatin resistance involved oxidative-stress pathways, especially NRF2-targeted genes in the GSH pathway (Fig

Acknowledgements The authors are grateful to the International Centre for Genetic Engineering (CRP/ NGA18-02, ICGEB) Italy, for the grant awarded to Amos Abolaji for the purchase of equipment, materials and resources used to carry out this project over the past years

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