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According to the study of Chen, IncRNA NEAT1 induces sorafenib resistance of HCC patients through repressing miR-335 expression and activation of c-Met-Akt signaling pathway (Chen and Xia, 2019)

[DOI] [PubMed] [Google Scholar] Mendoza-Cozatl DG, Butko E, Springer F, Torpey JW, Komives EA, Kehr J, Schroeder JI

10.1021/acsnano.4c04901 17 ChangX.WangS

Therefore, the link to in-depth applications in developmental studies is addressed as well as the proof of concept for applications of the lt-degron in biotechnologically relevant contexts