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Description

All one carbon metabolism (methylation) reactions occur within mitochondria

J.ElliottJ

By depleting GSH, CR increased the expression of Pepck-M, which can alter TCA flux

The authors also found that intestinal epithelial cell-specific Slc39a8 knockout (Slc39a8-IEC KO) mice have markedly decreased Mn levels in the blood and in most organs and develop colitis