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HIF-1 plays a key role in the growth, progression and metastasis of solid tumors (110, 111)

We assessed the effects of the drugs on the physiological status of diabetic mice by measuring blood glucose, body weight, and cell counts in several organs, as well as effects of thymulin and PRDX6 on the immune status of diabetic mice measuring concentrations of pro-inflammatory cytokines in blood plasma (TNF-, interleukin-5 and 17, and interferon-), activity of NF-B and JNK pathways, and Hsp90 expression in immune cells