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Keyword combinations included viral pneumonia, Traditional Chinese Medicine, natural products, inflammation, and oxidative stress, in addition to mechanism-related terms such as NF-B, Nrf2, PI3K/Akt, MAPK, and NLRP3 inflammasome. Natural compounds acting on these pathways have been shown to suppress cytokine storms, reduce reactive oxygen species accumulation, preserve alveolar epithelial integrity, and alleviate pulmonary inflammation

The glycans attached to milk proteins could be utilized by bifidobacterial (6), reshaping the composition of newborns microbiota (7)

As summarized in Table 4, preclinical and clinical studies support cardioprotective effects of metformin across diverse cardiac conditions, but large, rigorously designed trials are needed to define its role beyond metabolic indications

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