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This suggests that long-term maintenance on an LD rich in carbohydrates may confound some of the microbiome differences commonly reported between mice on HFDs and those on lean control diets which contain fewer carbohydrates

Semaglutide tends to produce weight loss measurable in weeks to months with a distinct path to significant outcomes, while AOD-9604 can exhibit slower and more modest fat-specific impacts over an extended period

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