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Extended outages If you are facing a multi-day outage during extreme heat, prioritize getting the medication to a refrigerated location

Proper cycling with off periods allows natural enzyme function to reset and may support long-term safety

The fingers have two IP joints: The distal interphalangeal (DIP) joint at the very end of the finger The proximal interphalangeal (PIP) joint in the middle of the finger The thumb has one IP joint at the junction between the middle and end of the thumb

No consistent pattern was seen with the median t max across the groups (72, 48, 48 and 60 h for normal renal function and mild, moderate and severe renal impairment, respectively)