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Mitochondrial metabolism serves a dual role in the cardiovascular system: it is the primary energy source for cardiomyocytes and a central integrator of overall cardiac health, and its dysfunction is a key driver of disease pathogenesis [128]

As Sherman and colleagues note, RWE can leverage data already collected during routine care, reducing both the time and expense required to generate evidence compared with initiating new trials

PMID: 35125818 | doi:10.3748/wjg.v28.i1.23

Insulin continues to be permissive for IGF-I production even after GH is established as the major pituitary stimuli controlling endocrine as well as paracrine/autocrine IGF-I, as described below