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Furthermore, a recent study has highlighted astrocyte-mediated epigenetic regulation as a key factor to affect autophagy in AD, implicating altered gene expression as a driver of disease pathology 13

Reactive astrocytes can also separate the ends from capillary endothelial cells (258)

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SASPs enable the primary senescent cells to direct adjacent or distant nonsenescent cells to experience secondary senescence in autocrine, paracrine, and juxtacrine manners ( FIGURE 1 3 The association between renal senescence and CKD As mentioned above, renal ageing and senescence share numerous similarities with CKD in renal and systemic manifestations