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Clinically, Tesamorelin is approved for the treatment of excess abdominal fat in HIV-infected individuals with lipodystrophy

The fragment corresponds to amino acid positions 176 to 191 of hGH and was identified as the region of the GH molecule responsible for its lipolytic fat-metabolising activity, separate from the anabolic and growth-promoting effects mediated by the GH receptor binding domains at the N-terminal end of the full molecule

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Because the vitamin deposits into muscle rather than entering the vasculature immediately, intramuscular delivery produces a sustained release effect